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防腐木自身的稳定性问题

来源:http://www.jnajgc.com 时间:2022-11-07

生物质基木材胶粘剂一般都是偏离中性的物质,因此所选防腐剂自身能在强酸、强碱条件下稳定,以利在胶粘剂的储藏时间内保持药物的浓度。济南防腐木如传统上使用的五氯酚钠见光受热时易分解,百菌清在强碱性分解释放HCl。这些特性也是防腐药剂选择的参考指标。
Biomass based wood adhesives are generally neutral substances, so the selected preservatives can be stable under strong acid and alkali conditions to maintain the drug concentration during the storage of adhesives. Jinan antiseptic wood, such as sodium pentachlorophenol traditionally used, is easy to decompose when exposed to light and heat, and chlorothalonil is decomposed in strong alkaline solution to release HCl. These characteristics are also reference indicators for selection of anti-corrosion agents.
20世纪70年代开发成功的BIT系列工业杀菌产品包括BIT原粉、PT液、BTC液、BTG液、BTX液等,主要活性成分为1,2-苯并异噻唑啉-3-酮。在pH4~12的范围内易溶,氨存在时稳定。对细菌、霉菌、酵母菌均有显着效果,且杀菌效率高,添加0.005%~0.05%即可。性能稳定,在200?高温下杀菌效力仍不变。使用方便,不产生污染,对金属无腐蚀。低毒,LD50>1400mg·kg-1。因此不仅在豆胶储藏中使用,即使经过热压(100~140?)也无妨,可以把药效维持到板材的防腐中;抗菌剂一定是具有抗微生物酶解的能力的抗代谢性,才能延长抗菌作用时间,如溴代肉桂醛不是酶促合成的天然有机物,在微生物体内不易被酶促分解,抗菌期可提高350倍。
The BIT series industrial bactericidal products successfully developed in the 1970s include BIT raw powder, PT solution, BTC solution, BTG solution, BTX solution, etc. The main active ingredient is 1,2-benzoisothiazoline-3-one. It is soluble in the range of pH 4~12 and stable in the presence of ammonia. It has significant effect on bacteria, mold and yeast, and has high sterilization efficiency. 0.005%~0.05% can be added. Stable performance at 200? The germicidal efficacy remains unchanged under high temperature. Easy to use, no pollution, no corrosion to metal. Low toxicity, LD50>1400mg · kg-1. Therefore, it is not only used in bean glue storage, even after hot pressing (100~140?) It is also OK to maintain the efficacy to the anti-corrosion of the plate; The antimicrobials must be antimetabolic with the ability of anti microbial enzymolysis in order to extend the antibacterial action time. For example, bromo cinnamaldehyde is not a natural organic substance that is enzymatically synthesized, and is not easy to be enzymatically decomposed in microorganisms. The antibacterial period can be increased by 350 times.
微生物的抗药性形成的机理及其对策
Mechanism and Countermeasure of Microbial Drug Resistance Formation
微生物基因轻微的突变就可以形成新的耐药性生理代谢新途径。新兴防腐技术核心是设法干扰微生物为抵抗各种环境而生存所进化形成的自我平衡调节机制。由于单一防腐剂抗菌、驱虫的范围比较狭窄,容易在短时间内诱导出微生物的抗药性。为了发挥防腐剂的Z大功效尽量降低其负面影响,采用防腐剂复配已经成为世界性的趋势,并取得了很好的效果。一般将2种或几种具有相加效应或协同效应防腐剂按一定比例合理混合,不但可以克服单一防腐剂使用时的不足,而且还会产生一些新的特性。如将具有不同抑菌机理的抗菌剂配合,产生单一药剂无法实现的超广抗菌谱,使得大多数的突变株都失去生存的基础。从而干扰微生物抗药性的形成,收到Z佳的防腐效果。
The slight mutation of microbial gene can form a new physiological metabolic pathway of drug resistance. The core of emerging anti-corrosion technology is to try to interfere with the self balance regulation mechanism evolved by microorganisms to survive against various environments. Due to the narrow scope of antibacterial and insect repellent of a single preservative, it is easy to induce microbial resistance in a short time. In order to give full play to the Z-effect of preservatives and minimize their negative effects, the use of preservatives has become a worldwide trend, and has achieved good results. Generally, two or more preservatives with additive or synergistic effects are reasonably mixed in a certain proportion, which can not only overcome the shortcomings of single preservatives, but also produce some new characteristics. If the antibacterial agents with different antibacterial mechanisms are combined to produce an ultra broad antibacterial spectrum that can not be achieved by a single agent, most of the mutants will lose the basis for survival. Thus, it interferes with the formation of microbial drug resistance, and receives Z's good anti-corrosion effect.